我们来自上海交通大学医学院国家热带病研究中心-全球健康学院。课题组由6名工作人员及多名硕士/博士研究生组成。 主要研究内容包含以老龄人群等为代表的重点人群健康有关的分子流行病学研究，主要包括重点人群发病因素研究、环境健康与重点人群健康的交互作用研究，基于多组学技术生物标志物研究等。 We are from the School of Global Health at the Chinese Centre for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine. Our research team consists of 6 staff members and multiple master's and doctoral students. Our primary research focuses include molecular epidemiology studies related to key populations such as the elderly. This includes research on disease factors in these populations, interactions between environmental health and population health, and biomarker studies based on multi-omics technologies. |
Derivation and validation of an epigenetic frailty risk score in population-based cohorts of older adultsDNA methylation (DNAm) patterns in peripheral blood have been shown to be associated with aging related health outcomes. We perform an epigenome-wide screening to identify CpGs related to frailty, defined by a frailty index (FI), in a large population-based cohort of older adults from Germany, the ESTHER study. Sixty-five CpGs are identified as frailty related methylation loci. Using LASSO regression, 20 CpGs are selected to derive a DNAm based algorithm for predicting frailty, the epigenetic frailty risk score (eFRS). The eFRS exhibits strong associations with frailty at baseline and after up to five-years of follow-up independently of established frailty risk factors. These associations are confirmed in another independent population-based cohort study, the KORA-Age study, conducted in older adults. In conclusion, we identify 65 CpGs as frailty-related loci, of which 20 CpGs are used to calculate the eFRS with predictive performance for frailty over long-term follow-up.
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